Searchable abstracts of presentations at key conferences in endocrinology

ea0015oc30 | Pituitary, disease | SFEBES2008

Local cortisol generation by human macrophage subsets by 11β-hydroxysteroid dehydrogenase type 1 enzyme and its role in ocular immune privilege

Joganathan Varajini , Al-Hakami Ahmed , Rauz Saaeha , Stewart Paul M , Wallace Graham R , Bujalska Iwona J

The eye is an organ vulnerable to a variety of external and internal stimuli that can abolish its vital function to allow accurate vision of images for survival. Inflammation is the key mediator of immune protection but its consequence leads to the disruption of the visual axis integrity. Due to this precise reason, through adaptation and evolution, the eye has developed mechanisms of immune tolerance and privilege. Glucocorticoids have potent immunosuppressive and anti-inflam...